2009; Flamment et al. 2012). Whilst some selenoproteins are important for skeletal muscle health and function (reviewed in (Rederstorff et al. 2006)) and SEPS1 is associated with metabolic disease (Karlsson et al. 2004; Du et al. 2008; Yu et al. 2016) including circulating plasma triglyceride concentrations in vivo (Walder et al. 2002), its specific role in response to excess saturated fatty acids in skeletal muscle has to date not been described. The gene discussed is SELENOS; the disease is metabolic disease.