NOTCH1 and heart failure: NOTCH1 was significantly associated with lower risk of heart failure in the CKD sub-group, but it was not significantly associated with HF outcomes in the non-CKD sub-group (CKD HR, [95%CI] 0.67 [0.56, 0.81], non CKD HR, [95%CI] 1.07 [0.82, 1.39], p-value for interaction 0.007.