FLT4 and chronic kidney disease: Vascular endothelial growth factor receptor 3, although it was not selected by random forest regression, was associated with higher risk of heart failure among patients with CKD (HR 1.4 [95%CI 1.16, 1.69]), and further, this was significantly higher risk than among patients without CKD (HR 1.04 [0.79, 1.37]) (p-value for CKD interaction 0.049).