The NOTCH1 pathway has central roles in endothelial cell senescence and atherogenesis.[32, 33] In angiogenesis, NOTCH1 in endothelial tip cells regulates angiogenic sprouting.[34, 35] Activation of NOTCH1 ameliorates cardiac injury after MI.[36] It is important to note that NOTCH1 is a cell membrane receptor, and we have measured it in the extracellular space. The gene discussed is NOTCH1; the disease is myocardial infarction.