Angiopoietin-2 (ANGPT2) was associated with higher risk of HF(HR[95%CI] 1.45[1.33, 1.59]), as was Spondin-1 (HR[95%CI] 1.45[1.33, 1.59]), while tartrate-resistant acid phosphatase type 5 (TRAP5) (HR[95%CI] 0.65[0.53, 0.78]) and neurogenis locus notch homolog protein 1 (NOTCH1) (HR[95%CI] 0.67[0.55, 0.80]) were associated with lower risk. Here, ACP5 is linked to hydrops fetalis.