INS and obesity due to melanocortin 4 receptor deficiency: The CTRP family is composed of 16 members including adiponectin (APN), like APN, the CTRP family members were believed to play a vital role in energy homeostasis, through altering insulin sensitivity specifically in the muscles and liver, all of which regulates whole-body energy metabolism thus, CTRPs could be novel pharmacological targets in T2D, obesity and inflammatory diseases [11].