This assumption also concurs with the proposed mechanism by Peterson et al. for CTRP3 that in the absence of insulin, CTRP3 suppresses gluconeogenic enzymes expression [glucose-6-phosphatase and phosphoenolpyruvate carboxykinase], resulting in a decreased glucose production in hepatoma cells [19]. This evidence concerns the gene C1QTNF3 and hepatocellular carcinoma.