ADA2 and neoplasm: The three expression clusters showed statistically significant differences in the PAN/K12A ratio with median ratios of 0.046 (Cluster I; IQR = 0.009:0.084), 0.1545 (Cluster II; IQR = 0.0138:0.297) and 1.635 (Cluster III; IQR = 1.026:2.092) (Fig 12B), indicating that the PAN/K12A ratio could be used to distinguish the different tumor clusters.