Studies of this microRNA have demonstrated inconsistent results, where miR-455-3p has been shown to be overexpressed and/or have oncogenic properties in KIT/PDGFRA mutant GISTs and esophageal squamous cell carcinoma [37,38], but acted as a tumor suppressor in melanoma, pancreatic and non-small cell lung cancers [39–41]. This evidence concerns the gene KIT and esophageal squamous cell carcinoma.