MYOC and glaucoma: Myocilin consists of three independently folded functional domains: i) the N-terminal domain, which contains two coiled coils and one leucine zipper motif, being involved in myocilin self-aggregation [11]; ii) the central linker domain, where calpain II cuts the polypeptide chain, splitting the N- and C-terminal domains [18, 19], and iii) the olfactomedin-like globular domain, which folds as a β-propeller [20] and carry most glaucoma-associated variants [2].