In this study, after a careful evaluation of the expression level of CRC‐related biomarkers in patient tissues and CRC cell lines (de Albuquerque et al., 2012; Cayrefourcq et al., 2015; Cohen et al., 2006; Gasch et al., 2013; Iinuma et al., 2011), we selected six genes—CEA, EpCAM,CK19,MUC1,EGFR and C‐Met—and evaluated their potential as biomarkers for CTC detection and prognostic prediction of CRC. Here, EGFR is linked to colorectal carcinoma.