In this study, after a careful evaluation of the expression level of CRC‐related biomarkers in patient tissues and CRC cell lines (de Albuquerque et al., 2012; Cayrefourcq et al., 2015; Cohen et al., 2006; Gasch et al., 2013; Iinuma et al., 2011), we selected six genes—CEA, EpCAM,CK19,MUC1,EGFR and C‐Met—and evaluated their potential as biomarkers for CTC detection and prognostic prediction of CRC. The gene discussed is MUC1; the disease is colorectal carcinoma.