Of 31 liver specimens available for pathologic examination, almost all revealed immune‐allergic features (21) with eosinophils, 28 with granulomas, thought to be caused by infiltration of portal triads within the liver by cytotoxic CD8+ cells.11 Review of the SmPC for AC reveals information regarding this risk group: “Hepatic events have been reported predominantly in males and elderly patients and may be associated with prolonged treatment” (Section 4.4 Special warnings and precautions for use).12 This evidence concerns the gene CD8A and Granuloma.