Less common syndromes and clinically relevant findings identified include multiple endocrine neoplasia type 2, carriers for ATM PVs, Von Hippel‐Lindau syndrome, CHEK2‐associated syndrome, constitutional mismatch repair deficiency, MUTYH‐associated syndrome, PALB2‐associated syndrome, hereditary leiomyomatosis, and renal cell cancer, Cowden syndrome, BRIP1‐associated syndrome, Li‐Fraumeni syndrome, NBN‐associated syndrome, and Neurofibromatosis type 1. The gene discussed is PALB2; the disease is Cowden disease.