CCNB1 and breast carcinoma: In parallel, evidence has showed that inhibition of CCNB1 expression renders breast cancer cells more sensitive to chemotherapy drug taxol (Androic et al., 2008), and CCNB1 is a biomarker for the prognosis of ER + breast cancer and monitoring of hormone therapy efficacy (Ding, Li, Zou, Zou, & Wang, 2014).