KCNMA1 and diabetes mellitus: For example, impaired BK channel functions in arteriolar smooth muscle cells presented in models of insulin resistance,31 diabetes,32, genetic obesity33 and hypertension.34 Therefore, our initial ideas proposed that prenatal hypoxia plus postnatal high‐fat diets may result in a down‐regulation of BK channels in MASMC of young adult offspring, as a mechanism for increased BP and PE‐mediated constriction of MA.