Previous studies also demonstrated that high‐fat diets could increase BK channel activities in middle cerebral arteries,35 aorta,36 and coronary arteries.37 It is well known that activation of BK channels induces vascular cellular membrane hyper‐polarisation,and then counteract vascular constrictions via reducing Cav1.2 channel activity.38 Therefore, in the present study, the HF‐increased BK activities may be temporary protective and compensatory measures for the elevated vasoconstrictions and BP. Here, CACNA1C is linked to hydrops fetalis.