Consistent with ZNF205‐AS1, EGR4 was also increased in NSCLC tissues, and the expression of EGR4 was significantly positively correlated with that of ZNF205‐AS1 in NSCLC tissues, supporting the positive regulation of ZNF205‐AS1 by EGR4. Here, ZNF205 is linked to non-small cell lung carcinoma.