EGR4 is a transcription factor, which belongs to the early growth response (EGR) family of immediate early genes.34 Previous study mainly focused on the roles of EGR4 in male infertility and neural development.35, 36 Matsuo et al reported that EGR4 promoted small cell lung cancer cell proliferation,25 but the expression and roles of EGR4 in NSCLC are still unknown. This evidence concerns the gene EGR4 and small cell lung carcinoma.