E‐cadherin expressed abundantly in most epithelial cells, but it is decreased at cell junctions during EMT (Jawhari et al., 1997), which is related to the metastasis of epithelial tumor cells by mediating of intercellular adhesion and acquiring mesenchymal phenotype, then facilitating cellular migration and invasion (Seidel et al., 2004). This evidence concerns the gene CDH1 and neoplasm.