FOS and Alzheimer disease: Through the binding of inducible proto-oncogenes c-fos and JunB to the activator protein-1 sequence present on the first intron of the SR gene, Aß promotes the transcriptional induction of SR (Wu and Barger, 2004), an observation which fits with the increase in SR messenger RNAs in the brain of AD patients (Wu et al., 2004).