In support, Vera et al showed that overexpression in MDA-MB-231 breast cancer cells, which express ∼three-fold more MASTL than MCF-10A cells (Rogers et al., 2018), could drive additional hyperproliferation, invasion and migration in these cells (Vera et al., 2015), suggesting a positive correlation between levels of MASTL and severity of the phenotypic outcomes. Here, MASTL is linked to breast cancer.