MASTL and cancer: Conversely, knockdown of MASTL can sensitize cancer cells to cisplatin, radiotherapy and 5-fluorouracil (5FU) in several cancer types (Wang et al., 2014; Nagel et al., 2015; Uppada et al., 2018; Yoon et al., 2018), most likely by preventing cells from re-starting the cell cycle following damage.