ITGAM and leukemia: It might, at first, appear like a contradiction that EAR-2 over-expression causes a complete block of leukemia cell differentiation (Fig. 2d shown by Gr-1-CD11b-and B220- in other words, almost no GR-1 + CD-11b + and B220+ cells were detected), whereas Fig. 3a shows that EAR-2 only partially inhibits myeloid cell differentiation (about 40% GR-1 + CD-11b + and 60% B220+ cells were detected in bone marrow cells ex vivo that overexpressed EAR-2).