In our previous work comparing the transcriptional profiles of individual proliferative and non-proliferative leukemia cells, we found that mRNA transcripts of v-Erb A related-2 (EAR-2, NR2F6) are more abundant in proliferative AML cells compared to AML cells that spontaneously growth arrest [32], suggesting that EAR-2 may increase proliferative ability, self-renewal and/or block differentiation. This evidence concerns the gene NR2F6 and leukemia.