The overall response rate was 40% in DLBCL with mutated EZH2 (n = 10) compared to 18% in patients with wild type EZH2 (n = 85); 63% in FL with EZH2 mutation (n = 8) compared to 28% in FL with wild type EZH2 (n = 46). This evidence concerns the gene EZH2 and diffuse large B-cell lymphoma.