IRF4 and Miyoshi myopathy: It was also shown to up-regulate transcripts related to apoptosis, Wnt, ID, MAPK, insulin signalling pathways and cellular differentiation [23], while it reduces the levels of MM-associated oncogenes JUNB, CD69, IRF-4, XBP-1, BLIMP-1 and c-MYC, presumably by modulating the expression of miRNAs [23, 24].