BACE1 and Alzheimer disease: Also, Shi et al in agreement with our study stated that CC genotype of polymorphism of BACE1 gene is associated with sporadic AD in Chinese Hans 38, although Kan et al indicated that there was a synergetic association between G-allele of G/C (rs638405) polymorphism and apolipoprotein E allele 4 with risk of Late-Onset AD in Chinese 20.