When AQP3 was experimentally knocked down in breast cancer cell lines, we noted a reduction in the active phosphorylated proteins extracellular signal-related kinase (ERK), protein kinase B (Akt), focal adhesion kinase (FAK), nuclear factor kappa light chain enhancer of activated B cells (NF-kB), and Src protein tyrosine kinase [our unpublished results]. Here, AKT1 is linked to breast carcinoma.