Activation of tyrosine kinases is essential in the progression from non-neoplastic mesothelial progenitor cells to mesothelioma [11] and FAK has been often described to promote malignancy by regulating tumorigenesis and metastasis through highly-coordinated signaling networks orchestrating invasion, EMT, angiogenesis and regulation of cancer stem cells [12]. This evidence concerns the gene PTK2 and cancer.