TP53 and cancer: In terms of KEGG pathways, the DEGs were mainly enriched in cell cycle (Williams and Stoeber, 2012; Otto and Sicinski, 2017), Fanconi anemia pathway (Ceccaldi et al., 2016), pyrimidine metabolism (Kelemen et al., 2014), and p53 signaling pathways, which were the cancer-related pathways.