Importantly, of the eight genes, MAD2L (Gogolin et al., 2013), CCNB1 (Liu et al., 2013; Schwermer et al., 2015), and BIRC5 (Lamers et al., 2011; Hagenbuchner et al., 2016) have been proven play important roles in NB development and metastasis. The gene discussed is CCNB1; the disease is neuroblastoma.