In the Tg2576 AD mouse model, administration of 4-PBA led to a decrease in tau phosphorylation by increasing GSK-3β (Ricobaraza et al., 2009) as well as increasing intraneuronal Aβ clearance and restoration of dendritic spine densities in hippocampal CA1 pyramidal neurons (Ricobaraza et al., 2012). This evidence concerns the gene MAPT and Alzheimer disease.