Importantly, the ADAM10 rs653765 CC genotype carriers exhibited a lower plasma sRAGE level than CT/TT genotype carriers among AD patients, suggesting that rs653765 C allele carriers might be less competent at antagonizing cell surface RAGE and thereby may be more susceptible to Aβ-induced cellular perturbation than carriers of the wild-type allele. The gene discussed is ADAM10; the disease is Alzheimer disease.