Our finding that melanoma-specific CXCR3+ precursors cells only induce TRM responses in vitiligo-affected hosts (111), together with studies showing that the CXCR3/CXCL9/10 axis is crucial for vitiligo development (120, 145), underscores how an autoimmune tissue microenvironment can provide a hospitable niche for tumor-specific TRM cell seeding (Figure 2). The gene discussed is CXCR3; the disease is melanoma.