Transcriptional analysis of this sorted CD103+CD39+ subset from five tumors (HNSCC and ovarian) revealed enrichment of gene transcripts associated with exhaustion and reduced expression of T cell recirculation associated genes, suggesting that CD103+CD39+ TILs may have the most pronounced TRM-like character in tumors (103). The gene discussed is ENTPD1; the disease is head and neck squamous cell carcinoma.