A few genes were downregulated 4 h after infection: caspase 8 (Casp8), nuclear receptor subfamily 2, group C, member 2 (Nr2c2/TAK1), mitogen-activated protein kinase 9 (Mapk9/JNK2) and interleukin 6 receptor-alpha (Il6ra). The gene discussed is IL6R; the disease is infection.