In the infected macrophages transfected with the let-7e inhibitor we detected the following upregulated genes 4 h after infection compared to infected NC-transfected macrophages: Tlr6, Tlr9, Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein (Tirap), Tnf receptor-associated factor 6 (Traf 6), Toll-like receptor adaptor molecule 1 (Ticam1), Tollip, Nfkbib/TRIP9, Nfkbil1, peroxisome proliferator activated receptor alpha (Ppara), Mapk8ip3/Jip3, Ptgs2/Cox2, colony-stimulating factor 2 (Csf 2/GMCSF), Hspd1, Csf3, interferon beta 1 (Infb1), Il6ra and Ilr1 (Figure 6C). The gene discussed is PTGS2; the disease is infection.