At 24 h after infection, the following genes were upregulated in infected macrophages transfected with the let-7e inhibitor compared to macrophages transfected with NC: Tlr7, Ly96/MD-2, Casp8, Map3k1, Mapk8, Ptgs2/Cox2, Csf 3/GCSF, and the ubiquitin-conjugating enzyme E2N (Ube2n). The gene discussed is CASP8; the disease is infection.