A study by Wang et al. (18), looking at chemerin mRNA expression in 19 SCCOT tumor tissues and matched adjacent tissues via qRT-PCR and IHC stains of 147 SCCOT specimen and their associated peritumoral, healthy tissues, determined that both chemerin mRNA and protein was upregulated in primary SCCOT specimens (18). This evidence concerns the gene RARRES2 and neoplasm.