MOG and Peripheral demyelination: In the second proposal for diagnostic criteria of Lopez-Chiriboga et al., similar findings are required: MOG-IgG seropositivity measured by a cell-based assay with clinical findings of ADEM, ON, CRION, TM, brain or brainstem syndrome compatible with demyelination, or any combination of the described syndromes, after exclusion of other differential diagnoses (69).