MOG antibodies have been found to be present in a subset of patients with ADEM, NMOSD, monophasic, and recurrent optic neuritis (ON), and transverse myelitis (TM), demyelinating syndromes overlapping with anti-NMDA receptor encephalitis or glycine receptor alpha 1 subunit antibody positive ON, Figure 1 (26, 27, 29–48). The gene discussed is MOG; the disease is acute disseminated encephalomyelitis.