MOG and leukodystrophy: In the absence of an unique imaging finding, typical features of MOG antibody positive patients are characterized as a normal brain MRI or large, confluent, poorly marginated MRI lesions (if clinically presenting with ADEM), LETM, perineural enhancement of the optic nerve, brainstem and hypothalamic lesions, and a leukodystrophy-like MRI pattern (25, 83).