GZMB and neoplasm: To corroborate that HLA-DR+ CTLs are activated lymphocytes with an anti-tumor activity profile, we assessed in pre-treatment samples, infiltrated HLA-DR+ CTLs and HLA-DR negative CTLs, the expression, by flow cytometry, of other effector immune response-related molecules, such as IFN-γ and Granzyme B, which are the most important players of activated CTLs.