In line with these former results, we also presented data that negatively correlate the level of HLA-DR in CTLs with the level of IL-6, IL-1β, IL-8, and IL-23/IL-12, which are inflammatory cytokines that, at certain level in the tumor microenvironment, could help the anti-tumor immune response (38), but whose upregulation might also favor tumor progression and metastasis (25–28). Here, IL1B is linked to neoplasm.