TNF and neoplasm: HLA-DR+ CTLs expressed higher levels of the cytolytic proteins Granzyme B (p = 0.02) and Perforin (p = 0.03); Eomes (p = 0.03), involved in differentiation of effector CTLs and the inflammatory cytokine TNFα (p = 0.03), which also has anti-tumor properties, in comparison with HLA-DR negative CTLs (Figure 5B).