On the other hand, the expression level of HLA-DR in Tregs was positively correlated with the expression of these pro-tumor molecules - IL-1β (r = 0.47, p < 0.01), IL-23/IL-12 (r = 0.43, p < 0.01), IL-6 (r = 0.48, p < 0.01) and IL-8 (r = 0.47, p < 0.001) – and, additionally, IL-10 (r = 0.44, p < 0.0001) and IL-17 (r = 0.45, p < 0.01), which could also undermine the activation of CTLs and lead to tumor progression (29, 30) (Figure 6). This evidence concerns the gene CXCL8 and neoplasm.