PSMA3 and spondylitis: As shown for T cells from healthy donors, PSMα3 increased the frequency of iTregs upon co-culture with LPS-treated mDCs by > 10-fold compared to LPS treatment alone (p = 0.024), whereas no effects were observed for Th1, Th2, and Th17 priming of T cells from patients with spondylitis (Figure 7A).