• Assess the relationships of TC, TG, HDL-C, ApoA, ApoB-100, Lp(a) with risk of common cancer forms, and total cancer mortality in comparison to incidence and mortality of CVD • Case-cohort sample out of the prospective EPIC–Heidelberg study, including a random subcohort (n = 2,739), and cases of cancer (n = 1,632), cancer mortality (n = 761), CVD (n = 1,070), and CVD mortality (n = 381). This evidence concerns the gene APOA1 and cancer.