In the logistic regression model, after controlling for age (Table 4), T2DM patients without any vascular complications when carrying lower methylation levels in NLRP3 CpG2 and AIM2 had 6.45 and 9.48 times higher risk (P = 0.045, P = 0.038) of developing diabetic microvascular complications than T2DM patients with higher methylation, respectively. Here, NLRP3 is linked to type 2 diabetes mellitus.