NLRP3 and type 2 diabetes mellitus: As shown in Figure 2, the total methylation level in the NLRP3, AIM2 and ASC promoter regions, NLRP3 CpG1, NLRP3 CpG2, NLRP3 CpG3, AIM2 CpG3, and ASC CpG1 methylation in T2DM without any complications were significantly higher than T2DM with micro-macrovascular complications (P < 0.05).