Interestingly, an exome sequencing study identified MANF as a potential causative gene for a 22-year-old woman patient with type 2 diabetes mellitus, hypothyroidism, primary hypogonadism, short stature, mild intellectual disability, obesity, deafness, high myopia, microcephaly and partial alopecia (Yavarna et al., 2015). This evidence concerns the gene MANF and obesity disorder.