TNF and myocardial infarction: In the processes of MI, genetic ablation of PLD1 resulted in defective migration of inflammatory cells into the infarct border zone, reduced TNFα and TGF-β secretion and smooth muscle α-actin expression of cardiac fibroblast leading to altered myofibroblast differentiation and interstitial collagen deposition in PLD1 deficient mice (Schonberger et al., 2014).