AR and posterior cortical atrophy: To date, several ligands have been identified to bind to the AF2 site, and exhibit potent activities in antagonizing the AR signaling, which inhibit the proliferation of AR dependent PCa cells (Andersen et al., 2010; Axerio-Cilies et al., 2011; Ravindranathan et al., 2013; Li et al., 2014; Munuganti et al., 2014).