TRIM14 and osteosarcoma: Conversely, studies showed that TRIM14 expression was up-regulated in hepatocellular carcinoma (HCC) [5], osteosarcoma [6], oral squamous cell carcinoma (OSCC) [7], tongue squamous cell carcinoma (TSCC) [8], breast cancer [9] and glioma [10], and that TRIM14 overexpression promoted cell proliferation, migration, invasion and chemoresistance, supporting the oncogenic role of TRIM14 in these cancers.