The wheezing information may suffer from recall bias; however, we applied a well-known validated instrument to measure asthma symptoms, which eases such bias.14,15 Atopy in the present paper was based only on symptoms of rhinitis or symptoms of eczema, without skin prick tests or IgE measurement; this is indeed a limitation in the interpretation of the results, although it has been used in several studies.24,25. The gene discussed is IGHE; the disease is rhinitis.