Given that the effect of HMGCLL1 inhibition on BCR-ABL1+ cell growth was mediated by the CDK4/6 pathway, CDK4/6 inhibitors such as palbociclib should be further investigated as a potential therapeutic option for CML treatment (Supplementary Fig. 9). Here, CDK4 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.