Constitutive activating mutations in the Wnt/β-catenin pathway play an essential role in the pathogenesis of CRC.19 (P)RR is proved crucial for Wnt/β-catenin-dependent tumourigenesis of pancreatic ductal adenocarcinoma23 and glioma.24 In the present study, we found that (P)RR level in CRC tissues showed a positive correlation with levels of active β-catenin and c-Myc, especially β-catenin translocation into nuclei. This evidence concerns the gene MYC and central nervous system cancer.