In agreement with our findings, Voloshanenko et al.19 demonstrated that Wnt3 expression is frequently higher in colon adenomas and carcinomas than in normal colon epithelium; Silencing of Wnt3 significantly decreased the activity of Wnt/β-catenin pathway in CRC cells with APC or β-catenin mutation and their proliferation. The gene discussed is WNT3; the disease is colon adenoma.