WNT3 and central nervous system cancer: Additionally, downregulation of (P)RR or Wnt3 induces cell apoptosis of glioma, pancreatic and gastric cancers by attenuating Wnt/β-catenin activity.23,24,36 In regard to the molecular mechanism responsible for the (P)RR-mediated Wnt3 regulation, we found that Wnt3 mRNA level was not affected by (P)RR silencing, suggesting that (P)RR regulates Wnt3 at the post-transcriptional level.