Furthermore, in CRC cell lines with APC loss-of-function mutation or β-catenin activating mutation, (P)RR silencing decreased Wnt3 protein level, as well as protein and mRNA levels of total LRP6, pLRP6, active β-catenin, Cyclin D1 and c-Myc. The gene discussed is LRP6; the disease is colorectal carcinoma.