IFNAR1 and colorectal neoplasm: Similar to our observations, it has also been reported that higher proportions of cells with IFNAR1 mRNA expression were detected in colorectal tumours than that in normal tissues41 and that 91.5% of pancreatic tumours and 88.9% of the periampullary tumours expressed IFNAR1, among which 23.4 and 13.0%, respectively, were strongly positive.42 The inconsistent results indicated that the function of IFNAR1 may vary in different solid tumours.