IFNA1 and cancer: IFNα is a double-edged sword in cancer, as it not only provides the necessary inflammatory signals but also initiates a feedback suppression of both immune and cancer cells.47 Traditionally, IFNα is considered beneficial and necessary to both promote T-cell responses and prevent metastases.47 However, accumulating evidences indicate that IFNα can also promote immunosuppression in several cancers.