The RNA profiling of 45 ER-regulated genes (Supplementary Table 2) revealed that short-term AZD9496 and fulvestrant treatments both effectively inhibited the residual expression of classic E2-induced genes (such as PGR and TFF1), further suggesting that both SERDs inhibited tumour growth, at least partly, by effective degradation and/or blockade of ER transcriptional activity. This evidence concerns the gene TFF1 and neoplasm.