SUCO and Alzheimer disease: While reports on MCI and early-stage clinical AD published so far (Fujishiro et al., 2006; Grothe et al., 2012; Kilimann et al., 2014; Vogels et al., 1990) support the idea of a later spreading atrophy from the posterior to anterior parts of the cholinergic forebrain (Mesulam, 2004a), we did already find an early involvement of the Ch1/2 complex.