For instance, osteosarcoma HOS cells resistant to JQ1 display increased levels of BRD2 and BRD4 concurrent with a reduction of BRD3 when compared to matched JQ1-sensitive control cells, highlighting that increased BRD3 function does not promote cell growth in this system and that its inhibition may have undesirable consequences (Lamoureux et al., 2014). Here, BRD4 is linked to osteosarcoma.