BRD3 and osteosarcoma: For instance, osteosarcoma HOS cells resistant to JQ1 display increased levels of BRD2 and BRD4 concurrent with a reduction of BRD3 when compared to matched JQ1-sensitive control cells, highlighting that increased BRD3 function does not promote cell growth in this system and that its inhibition may have undesirable consequences (Lamoureux et al., 2014).