On the other hand, the inhibitory effect of c-Src on Bub3/DMAP1/DNMT1 axis illustrates a critical way for cancer cells to resist mitotic stress, and this finding importantly provides a molecular basis for improving the therapy of pancreatic cancer that are refractory to anti-mitosis treatment with upregulated c-Src activity. The gene discussed is BUB3; the disease is familial pancreatic carcinoma.