In this study, we analyzed the influence of LARGE gene expression profile on VIA4–1 immunoreactivity in different types of muscular dystrophies, except for dystroglycanopathies [i.e. Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), sarcoglycanopathy, dysferlinopathy, calpainopathy, and merosin and collagen VI deficient CMDs]. This evidence concerns the gene LARGE1 and sarcoglycanopathy.