The set of mRNAs downregulated in both AKI and CKD models (Klotho, Lrp5, Suv39h2, Kdr and Epo) (Figs 4, 7 and S10–14) were not associated with matched decrease in Pol II levels suggesting that reduced message stability, rather than transcriptional suppression, play a more significant role in their lower expression. Here, LRP5 is linked to acute kidney injury.