TP53 and neoplasm: Interestingly, our screening also identifies TREND regulation to be caused by factors involved in genome surveillance or known to drive tumour suppressive programmes (e.g. TP53), and other processes involved in the coupling between oncogenic signals and 3′end processing (such as BARD114; details on TREND-affected targets, regulated Gene Ontology (GO) terms and executing TREND regulators are provided online, TREND-DB: http://shiny.imbei.uni-mainz.de:3838/trend-db).