PCF11 and neuroblastoma: Altogether, PCF11 thus represents a global key driver of TREND by directing APA in the BE(2)-C neuroblastoma model system in a direct and most efficient manner (Fig. 3a, Supplementary Figure 5a-c); PCF11 downregulation reshapes the transcriptome 3′end architecture reminiscent to that observed in mature neurons that typically show a more prevalent expression of long transcript isoforms39 (Fig. 2b, c, Supplementary Figure 3c).