In view of the central role of PCF11 for neurodifferentiation (Figs. 4g and 5e, Supplementary Figure 6c), for the regulation of APA of a neurodifferentiation operon (Fig. 3b) and the association with neuroblastoma prognosis (Fig. 5f, including high-risk neuroblastomas, Fig. 6a), we expected to identify corresponding TREND alterations in neuroblastoma patients, which mirror this functional association. Here, PCF11 is linked to neuroblastoma.