NFIL3 and colitis: A proinflammatory phenotype of NFIL3 deficiency is consistent with both the murine model, which develops colitis,11 and correlative data in humans, where NFIL3 expression is reduced in patients with colitis.12 While the patients described here have not presented with colitis, it is increasingly recognised that the clinical presentation of autoinflammatory diseases is diverse, with the underlying biological defect manifesting as different clinical symptoms in different individuals.