TOR1A and early-onset generalized limb-onset dystonia: Our autoradiography data showing a 15% reduction of DRD2 binding density in Tor1a+/− striatal sections are in striking resemblance with DRD2 binding reduction reported in caudate and putamen of DYT1 mutation carriers (Asanuma et al, 2005) and support the hypothesis of an enhanced degradation of the receptor, in accordance with previous data from different DYT1 dystonia models (Yokoi et al, 2011; Dang et al, 2012).