Using DeepSEA, the moderate-to-severe asthma risk allele (G) at the sentinel SNP rs11603634 near MUC5AC was predicted to result in a log2 fold change of more than 1·5 in function at Forkhead Box A1 (FOXA1) and Forkhead Box A2 (FOXA2) binding sites in airway epithelium (appendix). This evidence concerns the gene FOXA1 and asthma.