Slug is an important factor in STAT3-dependent enhancement of radioresistance, motility, and CSC properties based on the following findings: (i) STAT3 directly bound to the Slug promoter; (ii) STAT3 upregulated Slug and contributed to tumor invasion, radioresistance, and CSC properties; (iii) the coexpression of STAT3 and Slug in GBM enhanced radioresistance and correlated with poor prognosis. The gene discussed is STAT3; the disease is glioblastoma.